| Sabo, Mariah | Marine Naturalist Interpreter | Recreation | | |
| Sain, Cristin | Office Assistant | Recreation | | |
| Salazar, Juan | Superintendent | Public Works Municipal Operations | 949-718-3460 | |
| Saldana Iii, Ernest | Equipment Operator II | Public Works Municipal Operations | 949-718-3461 | |
| Saldivar, Humberto | Concrete Finisher | Public Works Municipal Operations | 949-718-3461 | |
| Saldivar, Ricardo | Recreation Leader | Recreation | | |
| Salerno, Robert | Firefighter 112 Hours | Fire | 949-644-3104 | |
| Salisbury, Mara | Marine Naturalist Interpreter | Recreation | | |
| Salvini, Barbara | Human Resources Director | Human Resources | 949-644-3259 | |
| Sanchez, Chris | Building Inspector, Principal | Community Development | 949-644-3266 | |
| Sanchez, Eric | Firefighter 112 Hours | Fire | 949-644-3113 | |
| Sanchez, Jessica | Permit Technician II | Community Development | 949-644-3287 | |
| Sanchez, Noe | Maintenance Worker I | Public Works Municipal Operations | 949-644-3084 | |
| Sanchez, Terry | Library Assistant | Library - City | 949-717-3895 | |
| Sanchez, Yair | Maintenance Worker I | Public Works Municipal Operations | 949-718-3461 | |
| Sanchez-Valencia, Alex | Utilities Specialist, Senior | Utilities | 949-718-4418 | |
| Sandefur, Thomas | Assistant City Engineer | Public Works | 949-644-3321 | |
| Sanders, Laurie | Librarian I | Library - City | 949-717-3827 | |
| Sanford, Ryan | Harbor Services Worker, Lead | Harbor Department | | |
| Santoni, Micah | Lifeguard I | Fire | | |
